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One still can, if one uses tools which are programmable.

Rather than use Autodesk Fusion 360, I use OpenSCAD, so when I wanted my own CAM setup I began work on: https://github.com/WillAdams/gcodepreview (which was muchly boosted by: https://pythonscad.org/ )

Rather than be limited by Quark XPress and PageMaker, I learned and used TeX which has allowed me to do pretty much anything I can write a (La)TeX macro for --- current project is a recursive macro which takes a list of water systems and their connections and outputs each system's connections --- but it allows one to do pretty much anything one needs: https://graphicdesign.stackexchange.com/questions/31088/any-...

That said, I did do a lot of AppleScript programming, and the InDesign integration was esp. nice (even managed to write a script which could manage four-level deep indexes which was said to be impossible by Adobe's Scripting Evangelist).

I'd love to see a list of scriptable opensource applications --- some notable ones from memory:

- LyX

- pyspread

- Krita



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