Yes, this study comes with the standard “in mice” caveat. We don’t know if this would replicate in humans. It is interesting though if for no other reason than to illustrate that all calorie sources are not equivalent.

Even in mice there is a large sex difference.Most beneficial in males.

This is a really good point. There are a lot of really odd outcomes these mice models consistently produce but we don't know what causes them and/or don't care because it's not within the scope of the primary research question

Some of us care ;-) including Dudley Lamming.

Here is our group’s latest paper in Science. We try to get at genetics of sex differences in lifespan:

https://pubmed.ncbi.nlm.nih.gov/36173858/

In this study we mapped 7 chromosomal regions that modulate lifespan in mice. We are now up to about 35 regions. Of course the goal is to understand the actual processes modulated by each so-called “locus”.