Not OP, but I use 2 mice. I use a KVM, but have one dedicated monitor for my work computer so it's always visible (and 2 shared amongst other machines). So I have 1 mouse on the KVM, and one on my work computer so I usually don't have to switch out of my non-work session to deal with something that pops up on the work machine. Also have a programmable usb 10-key with some canned responses. And, no, I can't remote into the work machine from the personal machines (regulated industry).
I moved the opposite way and got rid of my mouse for my desktop computer, so everything (except 3D work that is done with a drawing tablet) is done with the keyboard. Web browsing was the hardest to start doing without a mouse...