Hacker Newsnew | past | comments | ask | show | jobs | submitlogin

That's what you have studies for! Glad they caught it before it got into the wild.

Also, it's really great that there are multiple vaccines. Just imagine what happens when everyone gets a single vaccine that turns out to very often cause an adverse reaction...



All drugs have adverse side effects. The idea is the "therapeutic index" being the ratio of the good to the bad. In this case, balancing the risk of the vaccine against the reality of all the deaths that covid is causing.

Waiting for a zero risk vaccine is not the optimal decision.


But waiting for a reasonably safe and risk-free vaccine is, which is the point of the trials.


it is also true that this does not mean that this vaccine will not be the reasonably safe and risk-free one


[flagged]


A lot of people will die waiting for the vaccine. I haven't seen the CDC and FDA spokesmen take this publicly into account.


What's the alternative? A few months ago drug discovery chemist Derek Lowe wrote an article saying that frequently strict experimental procedures are the only way to tease out enough statistical power.


> enough statistical power

Meaning the adverse effects are small enough to require large numbers to discern. Balance this against the predictable number of covid deaths from waiting for those large numbers.


Most countries have already had SARS-2 work its way through them significantly. The utility of a vaccine might be lower than you think.

NZ comes to mind as a country that has barely built up any immunity (due to them trying to contain it completely). They can expect more utility from a vaccine than otherwise.

Anyway, given the incredibly low rate of both mortality and also any real consequences in, say, those under age 55, their personal benefit of a vaccine is incredibly low. So it really comes down to whether you’re a Sweden person or a New Zealand person.

I’m a Sweden person personally.


> Most countries have already had SARS-2 work its way through them significantly.

Noope, that isn’t what antibody testing shows. Take England for example. Coronavirus working its way through a mere, say, 6% of the population is devastating.

> The utility of a vaccine might be lower than you think.

Nonsense. We need to protect the other 94%.


The problem with aggregate numbers like that 6% is that they assume a uniform distribution of the virus within the population, which is not the case: some areas are far more hit than others. I think this should always be kept into account.


Yeah, in major population centres like London, about 20% of people caught it. Whereas rural England will be lower than that 6% average.

That’s the areas. As for age or demographics of people who caught it in England, I don’t think that is well known.


You're referring to antibody testing? Is any T-cell testing being done?


>The utility of a vaccine might be lower than you think.

Especially given that most Americans won't take it [0].

[0] https://www.axios.com/covid-vaccine-election-f267a641-a19f-4...


Isn't there already a protocol for early stopping if the effect sizes (positive or negative) are bit enough?


True, but the risk is to kill or disable more people than the virus could.


A lot seems to fall into this false dichotomy of “we must act with drastic measures else people die” mindset where said measures is just a bizarre cargo cult. Sad


The situation in Sweden suggests that any serious risk model cannot accept a wide scale vaccine solution within a near time window.


Not everyone. Just the ones who thought it was a good idea to get injected with a rushed vaccine.


And this is why trials must be allowed to run their course, not use vaccines as political propaganda, like what the Russian gangster and the orange clown are doing for their own political gains.




Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: